邮箱：chentongkai@gzucm.edu.cn
陈桐楷 CHEN TONGKAI 副研究员
所属学院（所）：科技创新中心/临床药理研究所
导师类别：硕士生导师
科研方向：纳米药物治疗肿瘤和脑部疾病
硕/博士招生学院：科技创新中心/临床药理研究所
招收学科类别：中药学
个人简述
陈桐楷，博士，副研究员，硕士生导师，从事新型纳米递药系统的构建及其克服生理屏障机制的研究，主要研究成果发表在Advanced Drug Delivery Reviews (IF: 15.52)，Nano-Micro Letters (IF: 9.04)，Journal of Controlled Release (IF: 7.90)，ACS Applied Materials & Interfaces (IF: 8.456)等国际著名期刊上。
学科领域
药学、中药学
教育背景
2013/09～2017/07，澳门大学，生物医药专业，获博士学位
工作经历
2017/09～至今，广州中医药大学，临床药理研究所
主要论文（近3年代表性论文）
1. Tongkai Chen*, Wei Liu, Sha Xiong, Dongli Li, Shuhuan Fang, Zhenfeng Wu, Qi Wang, Xiaojia Chen*. Nanoparticles Mediating the Sustained Puerarin Release Facilitate Improved Brain Delivery to Treat Parkinson’s Disease. ACS Applied Materials & Interfaces, 2019, doi: 10.1021/acsami.9b16047.
2. Chaoyin Wu, Benyue Li, Yi Zhang, Tingting Chen, Chuangrong Chen, Wei Jiang, Qi Wang*, Tongkai Chen*. Intranasal delivery of paeoniflorin nanocrystals for brain targeting. Asian Journal of Pharmaceutical Sciences, 2019, https://doi.org/10.1016/j.ajps.2019.11.002.
3. Yao Liu, Jingshan Luo, Xiaojia Chen, Wei Liu*, Tongkai Chen*. Cell membrane coating technology: A promising strategy for biomedical applications. Nano-Micro Letters, 2019, 11: 100.
4. Tongkai Chen, Bing He, Jingsong Tao, Yuan He, Hailiang Deng, Xueqing Wang, Ying Zheng. Application of Förster Resonance Energy Transfer (FRET) Technique to Elucidate Intracellular and In Vivo Biofate of Nanomedicines. Advanced Drug Delivery Reviews, 2019, 143: 177-205.
5. Sha Xiong#, Wei Liu#, Yile Zhou, Yousheng Mo, Yao Liu, Xiaojia Chen, Huafeng Pan, Dongsheng Yuan*, Qi Wang*, Tongkai Chen*. Enhancement of oral bioavailability and anti-Parkinsonian efficacy of resveratrol through a nanocrystal formulation. Asian Journal of Pharmaceutical Sciences, 2019, https://doi.org/10.1016/j.ajps.2019.04.003.
6. Sha Xiong#, Wei Liu#, Dongli Li#, Xiaojia Chen, Fang Liu, Dongsheng Yuan, Huafeng Pan, Qi Wang, Shuhuan Fang*, Tongkai Chen*. Oral delivery of Puerarin nanocrystals to improve brain accumulation and anti-Parkinsonian efficacy. Molecular Pharmaceutics, 2019, 16: 1444-1455.
7. Tongkai Chen, Jian Li, Ting Chen, Changquan Calvin Sun, Ying Zheng. Tablets of multi-unit pellet system for controlled drug delivery. Journal of Controlled Release, 2017, 262: 222-231.
8. Tongkai Chen, Chuwen Li, Ye Li, Xiang Yi, Ruibing Wang, Simon Ming-Yuen Lee, Ying Zheng. Small-sized mPEG-PLGA nanoparticles of Schisantherin A with sustained release for enhanced brain uptake and anti-Parkinsonian activity. ACS Applied Materials & Interfaces, 2017, 9(11): 9516-9527.
9. Tongkai Chen, Ye Li, Chuwen Li, Xiang Yi, Simon Ming-Yuen Lee, Ying Zheng. Pluronic P85/F68 micelles of baicalein could interfere with mitochondria to overcome multidrug resistance-associated protein 2 (MRP2)-mediated efflux and offer improved anti-Parkinsonian activity. Molecular Pharmaceutics, 2017, 14: 3331-3342.
10. Tongkai Chen, Chuwen Li, Ye Li, Xiang Yi, Simon Ming-Yuen Lee, Ying Zheng. Oral delivery of a nanocrystal formulation of Schisantherin A with improved bioavailability and brain delivery for the treatment of Parkinson’s disease. Molecular Pharmaceutics, 2016, 13: 3864-3875.
科研项目
1. 高水平大学建设杏林人才科研配套经费，2017/09-2020/09，40万，在研，主持。
2. 广东省自然科学基金，小粒径纳米晶体/聚合物胶束的跨膜转运特性及其在斑马鱼体内的吸收、分布、消除过程研究，2018/01～2020/12，10万，在研，主持。
3. 广东省医学科研基金，离子交换树脂缓释混悬剂的关键技术研究， 2019/07~2021/06，0.5万，在研，主持。
